Peptide to Block Mechanically Activated Ion Channels

Tech ID
5593
Description:
UB researchers have developed a potential drug candidate which acts on ion channels sensitive to tension in the cell membrane are involved in cellular regulation (Stretch Activated Channels or SAC). These channels, when uncontrolled, can lead to physiological states that are thought to contribute to diseases such as atrial fibrillation. Inhibition of these channels creates the possibility of limiting disease progression or a cure. A peptide, called GsMTx4, isolated from spider venom was shown to inhibit the activity of these channels and is the only known inhibitor specific for these channels. The peptide as it comes from the spider venom is composed of L-amino acids, and is folded in a unique conformation to achieve its 3-dimensional structure. This peptide can block cardiac arrhythmias associated with mechanical deformation in animals and the relevant ionic currents in cells. The toxin may be useful in a variety of pathologies associated with altered mechanical input such as volume regualation.  More
Patent Information:
For Information Contact:
Michael Fowler
Commercialization Manager
SUNY Buffalo
716 645 8136
mlfowler@buffalo.edu
Inventors:
Frederick Sachs
Tom Suchyna
Janice Delmar
Keywords:
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