Targeted Delivery of Dopamine Transporter Genes to Dopamine Neurons (MTA)
An adeno-associated virus vector delivering genes controlled by a tyrosine hydroxylase promoter to dopaminergic neurons. Adeno-associated viruses (AAVs) were created to specifically deliver genes to dopaminergic neurons. The proof-of-principle experiment delivered DAt under the control of a tyrosine hydroxylase promoter in a mouse model of dopamine...
Published: 11/18/2020
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Inventor(s): Caroline Bass, Patrick Fuller, Raul Gainetdinov
Keywords(s): Technologies
Category(s): Technology Classifications > Therapeutics and Vaccines, Campus > University at Buffalo
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Vaccine to Prevent Otitis Media and Infections in COPD
Moraxella catarrhalis antigen AfeA immunization of chronic obstructive pulmonary disease (COPD) patients. Chronic obstructive pulmonary disease (COPD) is a progressive and irreversible lung disease characterized by chronic inflammation reduced air flow. It is associated with smoke inhalation (typically from cigarettes or cooking fires) and air pollution...
Published: 11/18/2020
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Inventor(s): Timothy Murphy, Aimee Brauer
Keywords(s): Technologies
Category(s): Technology Classifications > Therapeutics and Vaccines, Campus > University at Buffalo
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Protein-Doped Hydrogel Dressing for General Wound Healing
A tunable, hydrogel-based wound healing device designed to enable focused and maximal delivery of biologically active therapeutics (e.g. growth factors) to the wound bed.Building on previous work, a team of UB scientists and physicians have developed a unique delivery device that enables directionally-controlled and sustained release of biologically...
Published: 11/18/2020
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Inventor(s): Joseph Gardella, Robert Hard, Frank Bright, Wesley Hicks, Chih-Chang Chu, Jennifer Appawu, Lynn Sigurdson, David Cohan, Michelle Marchany
Keywords(s): Technologies
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Drug Delivery, Campus > University at Buffalo
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In Situ Nonlinear Photon Conversion by Biological Medium to Produce Photodynamic Therapy
Novel photodynamic therapy for treating inaccessible and thick tumors.
Background:
Photodynamic Therapy (PDT) uses light to photoactivate drugs at the site of tumors causing a burst of free radicals which damage the tumor. The procedure has been used clinically for decades because of its ability to specifically target tumor regions. Unfortunately...
Published: 12/2/2020
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Inventor(s): Tymish Ohulchanskyy, Artem Pliss (non-UB), Aliaksandr Kachynski, Paras Prasad, Andrey Kuzmin
Keywords(s): Featured, Technologies
Category(s): Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Drug Delivery, Technology Classifications > Medical Devices, Campus > University at Buffalo
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Novel Vaccine Antigens for Moraxella Catarrhalis
Several vaccine targets developed to Moraxella catarrhalis, a pathogen found in otitis media (middle ear infection) and chronic pulmonary obstruction disease (COPD). Otitis media (OM), or middle ear infection, is one of the most common reasons for pediatric office visits. An estimated 30 million office visits can be attributed to OM every year. Eighty...
Published: 11/18/2020
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Inventor(s): Timothy Murphy, Charmaine Kirkham, Alan J Lesse
Keywords(s): Technologies
Category(s): Technology Classifications > Therapeutics and Vaccines, Campus > University at Buffalo
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High Throughput Cellular Screening for Development of Post-Transcriptonal Gene Silencing Agents against Arbitrary mRNA Targets
The development of RNA based therapies suffers from a bottleneck in identifying lead candidates that significantly knockdown target RNA in vivo. This is primarily due to the difficulties in predicting the dynamic secondary and tertiary structure of RNA. Currently, researchers begin by using software programs such as MFold and SFold. However, these...
Published: 11/18/2020
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Inventor(s): Jack Sullivan, Edwin Yau
Keywords(s): Technologies
Category(s): Technology Classifications > Research Tools and Reagents, Technology Classifications > Screens and Assays, Technology Classifications > Therapeutics and Vaccines, Campus > University at Buffalo
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A Vaccine to Prevent Infection by Nontypeable Haemophilus Influenzae infection
A vaccine to non-typeable Haemophilus influenzae (NTHi) based on OMP P2 with demonstrated effectiveness against greater than half of all tested NTHi strains.Currently, there is no effective vaccine to prevent infection by non-typeable Haemophilus influenzae (NTHi), a leading cause of otitis media as well as a number of other upper respiratory tract...
Published: 11/18/2020
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Inventor(s): Timothy Murphy, Thomas Hiltke, Sanjay Sethi
Keywords(s): Technologies
Category(s): Technology Classifications > Therapeutics and Vaccines, Campus > University at Buffalo
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Outer Membrane Protein B1 of Moraxella Catarrhalis
The present invention includes a method for the isolation and purification of outer membrane protein B1 as well as B1 peptides from Moraxella catarrhalis, and the resulting compositions. The method involves growing the bacteria in iron-depleted medium to enhance the expression of the B1 protein, harvesting the bacteria from the culture, extracting from...
Published: 11/18/2020
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Inventor(s): Anthony Campagnari
Keywords(s): Technologies
Category(s): Technology Classifications > Therapeutics and Vaccines, Campus > University at Buffalo
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Fluorocarbons as Anti-Inflammatory Agents
This invention is of special significance in the area of respiratory disorder diagnoses and treatment. It works by reducing the inflammatory response in various tissues of a patient by contacting the tissue with an effective, inflammation reducing amount of a liquid or gaseous fluorocarbon. Preferably, this tissue is either gastrointestinal or pulmonary,...
Published: 11/18/2020
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Inventor(s): Bradley Fuhrman
Keywords(s): Technologies
Category(s): Technology Classifications > Therapeutics and Vaccines, Campus > University at Buffalo
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